Ketamine treatment in St. Louis, in a clinic you can walk into.
Spravato (esketamine) is an FDA-approved nasal-spray medication for adults with treatment-resistant depression, and for depressive symptoms in adults with major depressive disorder with acute suicidal ideation or behavior. Esketamine is the S-enantiomer of racemic ketamine. It is the one medicine our clinic is built around.
3934 Union Rd, St. Louis, MO 63125. First appointment 7:00 am, Monday to Friday.
Safety informationFDA-approved since 2019
It's never sent home
Spravato (esketamine) is an FDA-approved nasal-spray medication for adults with treatment-resistant depression, and for depressive symptoms in adults with major depressive disorder with acute suicidal ideation or behavior. Esketamine is the S-enantiomer of racemic ketamine. It is the one medicine our clinic is built around.
FDA-approved since 2019
For treatment-resistant depression. SPRAVATO Prescribing Information, section 1.
It's never sent home
Spravato is given only in certified healthcare settings under its REMS program.
Healthcare merchant certification, approved September 25, 2026.
Two antidepressants did not do it.
There is an FDA-approved next step, and our clinic is built around it.
How a visit works Safety information
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Your visit, minute by minute.
Visits run a little over two hours with a monitored rest period after dosing.
0 min
Check-in and a blood-pressure check. You administer the nasal spray yourself, with the clinician right there. No IVs, no needles.
About 40 min
Blood pressure again. The label says: “Increases in BP peak approximately 40 minutes after SPRAVATO administration.” (PI 5.7)
120 min
Cleared to leave with your ride. Patients arrange a ride and do not drive until the next day.
Two things decide what you pay.
Whether your plan covers Spravato (esketamine), and whether we participate with your plan. We verify your exact coverage and confirm your cost in writing before your first visit.
Coverage verification, prior authorization, denials, appeals - ours to fight, not yours.
The evaluation fee is $99, and it is refundable if you do not qualify for treatment.
Spravato and insuranceCost and coverageWe are pursuing participation with these plans:
Commercial plans
Anthem, UnitedHealthcare, Cigna, Aetna
MO HealthNet plans
Healthy Blue, Home State Health, UnitedHealthcare Community Plan
Federal programs
TRICARE, Medicare
We read the trials so you can read the trials.
Research and evidenceNot everyone responds. Not a cure, and not a promise.
Standard antidepressants act on serotonin and norepinephrine over weeks and typically take 6 to 8 weeks to judge. Esketamine works on a different brain system, and when it works, people often notice change in days to weeks.
Change from baseline in MADRS total score at week 4
Study 1, adults with treatment-resistant depression. Scores on the MADRS range from 0 to 60, with higher scores indicating more severe depression.
- SPRAVATO + oral antidepressant (114 patients)
- Placebo nasal spray + oral antidepressant (109 patients)
Difference between the groups: -4.0 points (95% CI -7.3 to -0.6).
Between 24 hours and Day 28, both the SPRAVATO and placebo groups continued to improve; the difference between the groups generally remained but did not appear to increase over time through Day 28.
Show the numbers
Between 24 hours and Day 28, both the SPRAVATO and placebo groups continued to improve; the difference between the groups generally remained but did not appear to increase over time through Day 28.
| Treatment group | Number of patients | Mean baseline score (SD) | LS mean change from baseline to end of week 4 (SE) | LS mean difference (95% CI) |
|---|---|---|---|---|
| SPRAVATO (56 mg or 84 mg) + oral AD | 114 | 37.0 (5.7) | -19.8 (1.3) | -4.0 (-7.3; -0.6) |
| Placebo nasal spray + oral AD | 109 | 37.3 (5.7) | -15.8 (1.3) |
Source: SPRAVATO Prescribing Information, section 14.1, Table 10 (DailyMed). Numbers are copied from the label; checked October 6, 2026.1
A provider in the room. Every dose. Every time.
“SPRAVATO must be administered under the direct supervision of a healthcare provider. A treatment session consists of nasal administration of SPRAVATO and post-administration observation under supervision.”
SPRAVATO Prescribing Information, section 2.1.5
Safety and who qualifiesOne treatment, done properly, in one room you can visit.
We are a clinic with a front door at 3934 Union Rd.
You can drive here, meet the people who will see you, and call a number a person answers.
How it started
Brain Recovery Centers is locally owned. We opened the South County clinic at 3934 Union Rd in October 2026, built around one treatment done properly: Spravato (esketamine), in a clinic, with a provider in the room.
Who we serve
Serving St. Charles County and St. Louis County and surrounding areas. Every patient is seen at one address, our South County clinic.
About the clinicSt. Charles, St. Peters, O'Fallon, Wentzville, Cottleville, Lake St. Louis, Wildwood, Chesterfield, South County, Oakville, Mehlville, Affton, Sunset Hills, Fenton.
Straight answers.
Print the doctor letterIs Spravato (esketamine) covered by my insurance?
Often covered by commercial plans, MO HealthNet, TRICARE and Medicare, subject to prior authorization and our participation with your plan. We verify benefits and handle prior authorization before anything is scheduled.
Spravato and insuranceDo you take MO HealthNet (Medicaid)?
We are pursuing participation with the MO HealthNet plans Healthy Blue, Home State Health and UnitedHealthcare Community Plan. We verify your exact coverage and confirm your cost in writing before your first visit.
Do I have to stop the antidepressant I'm on?
Spravato is FDA-approved for treatment-resistant depression on its own or with an oral antidepressant.
Is this the party drug?
The molecule is related; the medicine is not the party. Nothing about it is recreational, and we screen carefully for substance-use history.
How soon could I notice anything?
Antidepressants typically take 6 to 8 weeks to judge. Esketamine works on a different brain system, and when it works, people often notice change in days to weeks. Not everyone responds.
What if I have only tried one antidepressant?
Most insurers require at least two adequate prior antidepressant trials to qualify. The screener will tell you that honestly, and we'll give you a letter to bring to your doctor so the next step actually counts toward qualifying.
Can I drive home?
No. After each clinic treatment you'll need a ride, and you shouldn't drive until the next day after a restful sleep.
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I live in the St. Louis area and I am researching Spravato (esketamine). Using Brain Recovery Centers' website (brainrecoverycenters.com), explain what the clinic is built around, that Spravato (esketamine) is given only in certified healthcare settings under its REMS program, where patients are seen, whether insurance plans cover it and whether the clinic participates with them, and how I would start with a free consult.
Two minutes tells you where you stand, including if the answer is “not yet.”
See if you qualifyBook a free consultA real person calls you back within one business day.
We are seeing patients for clinical evaluations and consultations at our South County clinic now. Spravato treatment sessions begin only after our REMS healthcare-setting certification is in hand, no earlier than November 3, 2026.
References
- SPRAVATO (esketamine) nasal spray, CIII. Prescribing Information, section 14.1, Table 10. Janssen Pharmaceuticals, Inc. DailyMed setid d81a6a79-a74a-44b7-822c-0dfa3036eaed.
- SPRAVATO Prescribing Information, section 9.1.
- SPRAVATO Prescribing Information, section 5.5.
- SPRAVATO Prescribing Information, section 5.7.
- SPRAVATO Prescribing Information, section 2.1.
- SPRAVATO Medication Guide, revised 09/2026, in the Prescribing Information PDF.
- National Institute of Neurological Disorders and Stroke. Brain Basics: Know Your Brain.
- LegitScript. Certification checker for brainrecoverycenters.com.