Where to read up, and where to look for care.
Most people land here in the middle of a bad stretch, trying to figure out what their options actually are. These 23 guides, directories and local health desks cover that ground - by town, by region, and by situation. Start with whichever one sounds like where you are.
Patients are seen at our South County clinic.
Our South County clinic is at 3934 Union Rd, St. Louis, MO 63125. Hours: Mon-Thu 7:00am-6:00pm, Fri 7:00am-2:00pm, closed Sat and Sun. South County clinic details and directions.
Our headquarters in Chesterfield, 18118 Chesterfield Airport Road, Suite G, Chesterfield, MO 63005, is an administrative office only. There are no patient visits at that address.
We are seeing patients for clinical evaluations and consultations at our South County clinic now. Spravato treatment sessions begin only after our REMS healthcare-setting certification is in hand, no earlier than November 3, 2026. Evaluations can start by telehealth. Details for each community:
Depression treatment: South County · Oakville · Mehlville · Affton · Sunset Hills · Fenton
PTSD treatment: South County · Oakville · Mehlville · Affton · Sunset Hills · Fenton
Your city
Local guides for St. Charles County towns - what care is nearby and how people actually get seen.
O'Fallon Mental Health
A plain-language guide to depression, anxiety and PTSD for O'Fallon and the Highway K and N corridors, with local treatment options.
On this site: Depression treatment near O'Fallon
Visit O'Fallon Mental HealthSt. Peters Mental Health
For St. Peters and the surrounding county: depression that won't lift, PTSD, and when it's reasonable to look beyond medication.
On this site: Depression treatment near St. Peters
Visit St. Peters Mental HealthWentzville Mental Health
Depression and PTSD explained for Wentzville and the fast-growing 63385 corridor, plus where treatment is within a short drive.
On this site: Depression treatment near Wentzville
Visit Wentzville Mental HealthSt. Louis and St. Charles
Metro-wide guides and provider directories covering both sides of the county line.
Depression Help STL
Warm, plain-talk support for people across St. Louis and St. Charles County who feel stuck on antidepressants and aren't sure what's next.
On this site: How Spravato works
Visit Depression Help STLThe St. Louis Mental Health Guide
A local desk covering treatment-resistant depression, PTSD, Spravato and TMS, crisis lines, insurance, and how to actually get an appointment.
On this site: Cost and coverage
Visit The St. Louis Mental Health GuideSt. Charles Therapy Finder
A directory of depression, trauma and mental-health options serving St. Charles County and greater St. Louis, including newer treatments.
On this site: Depression treatment near St. Charles
Visit St. Charles Therapy FinderSTL Depression Clinics
A directory of depression, TMS and Spravato (esketamine) providers serving the metro, searchable by location, treatment and insurance.
On this site: How Spravato works
Visit STL Depression ClinicsMissouri and the Midwest
Statewide and regional resources - useful if you're outside the metro or helping someone who is.
Missouri Depression Help
What depression treatments actually exist in Missouri, how to pay for them with MO HealthNet or insurance, and where to find help statewide.
On this site: Cost and coverage
Visit Missouri Depression HelpMissouri Mental Health Directory
A statewide directory of depression, PTSD and psychiatric care, organized by region and by the type of care you're looking for.
Visit Missouri Mental Health DirectoryMissouri PTSD Support
Trauma-aware PTSD information for Missouri veterans, first responders and their families, including TRICARE and VA coverage questions.
On this site: Veterans and military families
Visit Missouri PTSD SupportMidwest Mental Health Guide
What to try when antidepressants stop working, written for the Midwest, with a realistic look at how to find help in Missouri.
On this site: How Spravato works
Visit Midwest Mental Health GuideMidwest Depression Care
A regional directory of depression and mental-health care across Missouri and the greater Midwest, including advanced options for TRD.
Visit Midwest Depression CareDepression Treatment Finder
Helps you match your symptoms and situation to the treatment types and Missouri providers that fit - therapy and medication through TMS and Spravato.
On this site: Am I a candidate?
Visit Depression Treatment FinderLocal health desks
Longer-form reporting on how mental health care actually works in this region.
The St. Charles Health Desk
Local health reporting for St. Charles County on treatment-resistant depression, Spravato, TMS, PTSD, local resources and cost.
Visit The St. Charles Health DeskThe Gateway Health Review
Evergreen, plain-language coverage of depression, PTSD and modern treatment across the St. Louis metro and St. Charles County.
Visit The Gateway Health ReviewThe Midwest Health Dispatch
A health newsroom covering depression, anxiety, PTSD and modern psychiatric treatment across Missouri and the greater Midwest.
Visit The Midwest Health DispatchWhen the first treatments don't work
For the specific situation of having tried the standard options already.
When the Meds Don't Work
One in three people don't get better on antidepressants. An honest guide to what actually comes next, and how to raise it with your doctor.
On this site: How Spravato works
Visit When the Meds Don't WorkBeyond Antidepressants
Reflective, hopeful writing about what comes after the pills - newer options, realistic expectations, and how to talk to a prescriber.
Visit Beyond AntidepressantsTreatment-Resistant Help
An evidence-forward guide to treatment-resistant depression: what the term means, the approved next-line treatments, and what to expect.
On this site: Information for your doctor
Visit Treatment-Resistant HelpNational guides
Plain-language explainers you can read - or hand to someone - anywhere in the country.
First Line
You don't have to wait until you're out of options. A guide to today's real treatments, from therapy and medication to esketamine and TMS.
Visit First LineThe Depression Guide
A medically responsible guide to depression and clinician-supervised treatment, written so you can bring it to an appointment.
Visit The Depression GuideThe Way Through
A hopeful publication about depression and modern treatment, built around one idea: ask for help earlier than you think you should.
Visit The Way ThroughModern Mental Health
A national guide to modern depression and PTSD care - talking therapy, medication, esketamine and TMS - and how to ask for help early.
Visit Modern Mental HealthTwo counties, one clinic - care across the greater St. Louis metro.
Serving St. Charles County and St. Louis County and surrounding areas. Patients are seen at our South County clinic in St. Louis; our headquarters in Chesterfield is an administrative office with no patient visits. Whether you're coming from St. Charles County or from anywhere on the St. Louis side, you're in the right place.
Not sure which one applies to you?
Two minutes of questions and we'll tell you honestly where you stand - clinic or not yet.
Start the 2-minute screenerBook a free consultA real person calls you back within one business day.
We are seeing patients for clinical evaluations and consultations at our South County clinic now. Spravato treatment sessions begin only after our REMS healthcare-setting certification is in hand, no earlier than November 3, 2026.