For your physician

Print this. Hand it to your doctor.

Most people trust their own doctor most - as they should. This page gives your physician everything they need in one look.

To my doctor:

I'd like to be evaluated for esketamine (Spravato) treatment for depression that hasn't responded to the antidepressants I've tried. Could we talk about whether a referral makes sense - and if I don't meet criteria yet, which next medication trial would count toward them?

For the clinician

  • Indication: Spravato (esketamine CIII nasal spray) is FDA-approved for treatment-resistant depression in adults, as monotherapy or in conjunction with an oral antidepressant. It is also approved, in conjunction with an oral antidepressant, for depressive symptoms in adults with major depressive disorder with acute suicidal ideation or behavior.
  • Typical payer criteria: two or more adequate oral antidepressant trials in the current episode; concurrent oral antidepressant during treatment.
  • Administration: REMS program - administered only in certified healthcare settings with 2-hour post-dose observation; never dispensed for home use.
  • Our role: Brain Recovery Centers serves St. Charles County and St. Louis County, handles benefits verification and prior authorization, and returns outcome measures (PHQ-9, and PCL-5 where relevant) to you at the interval you prefer, with patient consent.
  • Referral & records: call (314) 314-9112 to coordinate; the patient can also self-refer via the screener at our site.
  • For clinicians: brainrecoverycenters.com/for-providers

Want us to talk to your doctor's office directly instead? Start the screener and check "my doctor is involved" - we'll take it from there.

Safety information

From the SPRAVATO Medication Guide, revised 09/2026. These are excerpts, word for word.

What is the most important information I should know about SPRAVATO?

SPRAVATO may cause serious side effects, including:

How can I watch for and try to prevent suicidal thoughts and actions in myself or a family member?

Pay close attention to any changes and tell your healthcare provider right away if you develop any new or sudden changes in mood, behavior, thoughts, or feelings, or if you develop suicidal thoughts or actions. This is very important when SPRAVATO is started or when the dose is changed.

Tell your healthcare provider or get emergency help right away if you or your family member have any of the following symptoms, especially if they are new, worse, or worry you:

If you're in crisis right now, call or text 988 (Suicide & Crisis Lifeline), or go to your nearest emergency room. Brain Recovery Centers is not an emergency service.

Who should not take SPRAVATO?

Do not take SPRAVATO if you:

If you are not sure if you have any of the above conditions, talk to your healthcare provider before taking SPRAVATO.

Before you take SPRAVATO, tell your healthcare provider about all of your medical conditions, including if you:

What should I avoid while taking SPRAVATO?

Do not drive, operate machinery, or do activities that require you to be fully alert and coordinated after taking SPRAVATO. Do not take part in these activities until the next day following a restful sleep.

What are the possible side effects of SPRAVATO?

Increased blood pressure. SPRAVATO can cause a temporary increase in your blood pressure that may last for about 4 hours after taking a dose. Your healthcare provider will check your blood pressure before taking SPRAVATO and for at least 2 hours after you take SPRAVATO. Tell your healthcare provider right away if you get chest pain, shortness of breath, sudden severe headache, change in vision, or seizures after taking SPRAVATO.

Problems with thinking clearly. Tell your healthcare provider if you have problems thinking or remembering.

Bladder problems. Tell your healthcare provider if you develop trouble urinating, such as a frequent or urgent need to urinate, pain when urinating, or urinating frequently at night.

The most common side effects of SPRAVATO include:

If these common side effects occur, they usually happen right after taking SPRAVATO and go away the same day.

These are not all the possible side effects of SPRAVATO. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the full Medication Guide (PDF)

Read the full Medication Guide (PDF)