For athletes and former athletes

You Got Your Bell Rung. Now Something Feels Off.

You walked it off. You finished the season. Years later the depression won't lift, the fog won't clear, and the antidepressants aren't touching it. There may be a reason nobody has checked for.

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Recognition

If you played through hits, this may sound familiar

  • Depression that antidepressant after antidepressant hasn't moved
  • A shorter fuse than you used to have, and you know it
  • Fog, word-finding slips, walking into a room and forgetting why
  • Sleeping eight hours and waking up exhausted
  • Drive, focus, and motivation that quietly went missing
  • A sense that you haven't felt fully like yourself in years

You do not need a diagnosis on paper. Between 40 and 80 percent of concussions are never reported at the time they happen. “There's nothing in my chart” is expected, not reassuring.

The common thread

Whichever Story Is Yours, the Biology Rhymes

An old hit can show up across eight areas: mood, thinking and memory, sleep, energy and hormones, the body's autopilot, balance and vision, headache and sensory sensitivity, and personality. Standard depression care usually looks at only one.

  • People with a history of a bell-ringing hit are more than three times more likely to have depression than people without. (Beaton et al. 2020, meta-analysis, Frontiers in Neurology)
  • Standard antidepressants often can't reach this population. A meta-analysis of antidepressants for depression after a head impact found no significant difference from placebo. (Foreman et al. 2019, J Head Trauma Rehabil)
  • Ketamine and esketamine (Spravato®) work on a different system entirely, glutamate, with effects measurable in hours and a 24 to 72 hour neuroplasticity window. (Zanos & Gould 2018, Molecular Psychiatry)

We do not claim to repair, reverse, or cure a concussion or any brain injury. What we do is treat the depression that a head-injury history can make more likely, and more resistant to standard care. A head-injury history is a risk factor for that depression, not an indication for ketamine itself.

Why a clinic with neurology available to consult is different

What a Clinic With Neurology Available to Consult Can Actually Look At

Depression that follows a bell-ringing hit often has a driver ordinary depression care never checks for. A GP managing fatigue or a psychiatrist managing mood usually is not looking across the whole picture. Because we have neurology available to consult, we can:

Screen the hormone axis

A hit can bruise the pituitary, the master hormone gland, and up to 1 in 6 people develop a deficiency (low thyroid, testosterone, or growth hormone) that looks exactly like getting older.

Take sleep seriously

Sleep disorders affect roughly 30 to 70 percent of people with a head-injury history (Viola-Saltzman and Watson, 2012, Neurologic Clinics), and broken sleep keeps depression from lifting.

Check the autonomic system

A hit can disrupt automatic control of heart rate and blood pressure, which is why some people feel dizzy standing up or exhausted for no clear reason.

Take a real head-injury history

The hit is often remote, years or decades back, and rarely asked about. Connecting it to today's symptoms is the whole point.

This is capability, not a promise of a specific outcome. It means we know where to look before we recommend anything.

One front door

It All Starts With a Recovery Evaluation

Everything begins with a Recovery Evaluation, a proper clinical evaluation from a clinic with neurology available to consult, not a sales call. It is $99, fully refunded if you don't qualify. If you do, the treatment pathway is Spravato in our clinic.

Spravato® in our clinic

FDA-approved for treatment-resistant depression. Given only in certified healthcare settings under its REMS program, with supervision and two-hour monitoring, and often covered by commercial plans, MO HealthNet, TRICARE and Medicare, subject to prior authorization and our participation with your plan. We verify your exact cost first.

Your PHQ-9 is measured at every visit, so you see the numbers move, not just how you feel.

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Your free guide

The Hit List: 12 Signs an Old Concussion Is Still Running Your Brain

A plain-language guide, no cost, no obligation. Start the screener and we'll point you to it.

Or start here

A Recovery Evaluation is the one front door. $99, fully refunded if you don't qualify. If you do, Spravato in clinic opens up.

How we keep this safe

Safety & Compliance

Spravato under its REMS program

Every dose is observed by a healthcare provider, with two-hour post-dose monitoring and blood-pressure checks before you leave.

No driving until the next day

Someone drives you home, and per the FDA label you do not drive again until the next day, after a restful sleep. This is a firm rule, not a suggestion.

We screen for substance use

This treatment is not compatible with active substance use, and we screen for it carefully.

Crisis: if you or someone you know is in crisis, call or text 988 (Suicide and Crisis Lifeline) or go to your nearest emergency room. Brain Recovery Centers is not an emergency service.

Spravato® (esketamine) is FDA-approved for treatment-resistant depression and for depressive symptoms in adults with major depressive disorder with acute suicidal ideation or behavior. It is not FDA-approved for concussion, traumatic brain injury, or post-concussion syndrome. Use in patients with a concussion history is based on clinical judgment regarding the depression component. We do not offer IV ketamine infusions. This page is educational and not medical advice. Individual results vary.

Common questions

I never had a diagnosed concussion. Does this still apply to me?

Yes, quite likely. Most concussions never make it onto a chart. If you ever got your bell rung, it counts, and even hits that were never called a concussion can affect the brain long-term.

Why try ketamine when other antidepressants haven't worked?

That is exactly the point. Antidepressants act on serotonin and norepinephrine, and the depression that follows a head impact often runs on a different system. Ketamine and esketamine act on glutamate, which is why we lead with this pathway for people with this history.

What is the first step and what does it cost?

A Recovery Evaluation, $99 and fully refunded if you do not qualify. It is a proper clinical evaluation from a clinic with neurology available to consult, not a sales call.

Standard Treatment Hasn't Worked Because It May Not Be Standard Depression.

Start with a Recovery Evaluation. $99, fully refunded if you don't qualify. Or take the 2-minute screener first.

Start the 2-minute screener Book a free consult

Prefer to talk it through? Call us at (314) 314-9112.

Safety information

From the SPRAVATO Medication Guide, revised 09/2026. These are excerpts, word for word.

What is the most important information I should know about SPRAVATO?

SPRAVATO may cause serious side effects, including:

How can I watch for and try to prevent suicidal thoughts and actions in myself or a family member?

Pay close attention to any changes and tell your healthcare provider right away if you develop any new or sudden changes in mood, behavior, thoughts, or feelings, or if you develop suicidal thoughts or actions. This is very important when SPRAVATO is started or when the dose is changed.

Tell your healthcare provider or get emergency help right away if you or your family member have any of the following symptoms, especially if they are new, worse, or worry you:

If you're in crisis right now, call or text 988 (Suicide & Crisis Lifeline), or go to your nearest emergency room. Brain Recovery Centers is not an emergency service.

Who should not take SPRAVATO?

Do not take SPRAVATO if you:

If you are not sure if you have any of the above conditions, talk to your healthcare provider before taking SPRAVATO.

Before you take SPRAVATO, tell your healthcare provider about all of your medical conditions, including if you:

What should I avoid while taking SPRAVATO?

Do not drive, operate machinery, or do activities that require you to be fully alert and coordinated after taking SPRAVATO. Do not take part in these activities until the next day following a restful sleep.

What are the possible side effects of SPRAVATO?

Increased blood pressure. SPRAVATO can cause a temporary increase in your blood pressure that may last for about 4 hours after taking a dose. Your healthcare provider will check your blood pressure before taking SPRAVATO and for at least 2 hours after you take SPRAVATO. Tell your healthcare provider right away if you get chest pain, shortness of breath, sudden severe headache, change in vision, or seizures after taking SPRAVATO.

Problems with thinking clearly. Tell your healthcare provider if you have problems thinking or remembering.

Bladder problems. Tell your healthcare provider if you develop trouble urinating, such as a frequent or urgent need to urinate, pain when urinating, or urinating frequently at night.

The most common side effects of SPRAVATO include:

If these common side effects occur, they usually happen right after taking SPRAVATO and go away the same day.

These are not all the possible side effects of SPRAVATO. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the full Medication Guide (PDF)

Read the full Medication Guide (PDF)