Research · First-party survey data

Midwest Depression Care Survey 2026

What 443 adults across ten Midwest states said about depression that standard medication did not help, where they would go first, whose advice they trust, and how they would pay for care. These are the full topline results, published here as the single citable source for this survey.

Respondents 443 adults, 18 to 64States MO, IL, IA, NE, KS, OK, IN, OH, WI, MNClosed June 23, 2026Status Final, validated data

Headline findings

In plain language. Every figure is a share of all 443 respondents, from the final validated data.

  • A doctor's word outweighs advertising74 percent said a recommendation from their own doctor would most make them try a new depression treatment. 2 percent said an ad.
  • Most people would start with their primary doctor56 percent would go to their primary doctor first. 12 percent would search online themselves.
  • Few have heard of Spravato73 percent had never heard of Spravato (esketamine). 6 percent said they know what it is.
  • Insurance coverage leads every other factor85 percent ranked "covered by insurance" among the two things that matter most when choosing a provider.
  • Commercial insurance and Medicaid are nearly tied39 percent are covered by commercial or private insurance, the largest group, with Medicaid a close second at 37 percent. 23 percent have Medicare.
  • Depression that standard medication did not help is common72 percent have personal or close experience with depression, anxiety, or PTSD that did not improve on standard medication.
  • Open far more often than opposed51 percent were open to ketamine therapy for depression or PTSD (cautious but open, or hopeful). 9 percent reacted negatively.
  • A general-population sampleAbout 7 percent are themselves a veteran, active military member, or first responder (29 of 443). Most respondents, 58 percent, have no such connection.

Full topline results

Each table shows every answer with its share of respondents and raw count. Shares are rounded to whole percents, so a column may not sum to exactly 100. Multi-select questions total more than 100 percent. How answers differ by group follows in the group breakdowns.

SQ1Consent screenerScreener · n=443
AnswerShare of respondentsCount
Yes, 18 or older and I consent100%443
No, I would rather not take part0%0

Everyone who did not consent was screened out, so all 443 completes consented.

Q2Which best describes you?Single selection · n=443
AnswerShare of respondentsCount
None of the above58%258
Parent or family member of a veteran or first responder29%129
Spouse or partner of a veteran or first responder6%27
First responder (police, fire, EMS)4%18
Veteran or active military2%11

About 7 percent are themselves a veteran, active military member, or first responder (29 of 443). Combined, 42 percent have some connection.

Q3Have you, or someone close to you, struggled with depression, anxiety or PTSD that did not improve on standard medication?Single selection · n=443
AnswerShare of respondentsCount
Yes, myself37%166
No28%124
Yes, someone close to me22%97
Both13%56

Combined, 72 percent answered yes in some form, and 50 percent said it was themselves (yes, myself, or both).

Q4If you were looking for help, what exact words would you type into Google?

Open text · n=319 answered. Examples of what people typed, shown as written. Respondents typed symptoms and requests for help; almost none typed a drug name.

  • “help with depression”
  • “help with ptsd”
  • “ptsd help”
  • “how to help someone with depression”
  • “depression medicine alternatives”
  • “ptsd treatments”
  • “therapist near me”
  • “how to overcome depression”
  • “best ways to handle depression”
  • “how to cope with my anxiety”
  • “help with mental health”
  • “someone please help me”
  • “depressed”
Q5Before today, had you heard of Spravato (esketamine)?Single selection · n=443
AnswerShare of respondentsCount
No73%324
I've heard the name21%92
Yes, I know what it is6%27

Combined, 94 percent could not say what Spravato is (had never heard of it, or had heard the name only).

Q6What is your first reaction to "ketamine therapy for depression or PTSD"?Single selection · n=443
AnswerShare of respondentsCount
Cautious but open34%150
Skeptical21%94
Never heard of it18%79
Hopeful or curious18%78
Negative, it sounds like a drug9%42

Combined, 51 percent were open (cautious but open, or hopeful or curious) and 31 percent were skeptical or negative.

Q7How much would "covered by insurance" change whether you would try it?Single selection · n=443
AnswerShare of respondentsCount
Big impact43%191
It's the deciding factor22%96
Some21%94
None14%62

Combined, 65 percent said insurance is the deciding factor or a big factor.

Q8How much would "FDA approved" change whether you would try it?Single selection · n=443
AnswerShare of respondentsCount
Big impact40%178
Some27%121
It's the deciding factor19%83
None14%61

Combined, 59 percent said FDA approval is the deciding factor or a big factor.

Q9Would you choose (A) covered by insurance with more hoops, or (B) pay yourself and simpler to start?Single selection · n=443
AnswerShare of respondentsCount
Option A: covered by insurance, more hoops51%224
Not sure, depends26%115
Option B: pay myself, simpler to start23%104
Q10If you wanted this treatment, who would you go to first?Single selection · n=443
AnswerShare of respondentsCount
My primary doctor56%250
A psychiatrist or mental health provider23%102
Search online myself12%51
I wouldn't know where to start5%22
Ask a friend or family member1%6

One further answer option, chosen by 12 of 443 respondents (3 percent), is not shown.

Q11If available, how would you prefer to receive it?Single selection · n=443
AnswerShare of respondentsCount
In person at a local clinic44%194
Start in a clinic, then move to at-home23%103
At home via telehealth (medication shipped to me)22%98
No preference or not sure11%48

Combined, 67 percent want a clinic involved (in person, or starting in a clinic and then moving home).

Q12Whose recommendation would most make you actually try it?Single selection · n=443
AnswerShare of respondentsCount
My own doctor74%330
A close friend or family member18%79
A veteran or first responder I follow online4%18
An ad I saw2%10
A podcast host I trust1%6
Q13Do you know what TMS is, and would "drug-free, less invasive" make you more comfortable?Single selection · n=443
AnswerShare of respondentsCount
Don't know TMS, but drug-free matters51%224
Don't know TMS, doesn't matter25%109
I know TMS, and drug-free matters a lot13%59
I know TMS, doesn't change much12%51

Combined, 64 percent said drug-free matters; 25 percent know what TMS is.

Q14When choosing a provider, which two matter most?Multiple selection (pick two) · n=443
AnswerShare of respondentsCount
Covered by insurance85%376
Close to home43%192
FDA-approved and proven27%119
Fast results24%108
Private or discreet11%48
Specializes in veterans and first responders10%43

Respondents picked two, so shares total more than 100 percent.

Q15Which of these covers you?Multiple selection · n=443
AnswerShare of respondentsCount
Commercial or private insurance39%173
Medicaid37%163
Medicare23%100
None, uninsured9%39
TRICARE (military)5%20
Prefer not to say2%11

Respondents could pick more than one, so shares total more than 100 percent.

Group breakdowns

How answers differ across groups of respondents. Each figure is the share of that group, and each group's size is shown as n. The first row is all 443 respondents, for comparison. Only groups of 30 or more respondents are reported. TRICARE members (20 respondents) and respondents who are themselves a veteran or first responder (29) are too small to report, so no figures are given for either. The St. Louis TV market group is small (31), so read it with care. Coverage groups overlap, because respondents could name more than one type of coverage.

Awareness, openness and who they trustShare of each group · groups of 30 or more respondents
GroupRespondents (n)Never heard of SpravatoOpen to ketamine therapyOwn doctor would move them mostWould go to primary doctor firstPrefer an in-person clinicDrug-free option matters
All respondents44373%51%74%56%44%64%
Covered by Medicaid16369%55%75%61%45%63%
Covered by commercial insurance17374%49%81%57%40%71%
Covered by Medicare10072%48%69%60%50%56%
Uninsured3985%56%67%51%38%54%
Family or spouse of a veteran or first responder15664%57%73%60%49%72%
Parents or family of a veteran or first responder12964%55%75%63%52%71%
Ages 18 to 3414270%53%71%51%44%61%
Ages 35 to 4917170%54%70%56%46%60%
Ages 50 to 6413081%46%84%64%40%72%
Women27976%49%75%58%42%65%
Men16468%55%74%53%47%62%
Missouri residents5575%55%65%45%38%71%
St. Louis TV market3174%58%68%61%48%61%
Personally had depression that standard medication did not help22270%55%73%53%47%60%
Insurance and what they weighShare of each group · groups of 30 or more respondents
GroupRespondents (n)Insurance is a deciding or big factorRank insurance in top twoChoose covered with hoops over self-payFDA approval is a deciding or big factorRank close to home in top two
All respondents44365%85%51%59%43%
Covered by Medicaid16368%90%57%65%45%
Covered by commercial insurance17367%84%50%54%43%
Covered by Medicare10064%86%58%60%45%
Uninsured3956%72%38%54%49%
Family or spouse of a veteran or first responder15667%83%51%67%42%
Parents or family of a veteran or first responder12964%84%48%64%43%
Ages 18 to 3414273%82%52%61%46%
Ages 35 to 4917162%85%51%57%43%
Ages 50 to 6413060%88%48%59%41%
Women27963%87%50%57%42%
Men16467%82%52%62%45%
Missouri residents5558%93%44%51%42%
St. Louis TV market3148%90%39%58%39%
Personally had depression that standard medication did not help22269%87%55%64%45%

Methodology

Panel
Pollfish consumer panel, survey 395586438.
Fieldwork
Closed June 23, 2026.
Sample
n=443 completed responses from adults aged 18 to 64.
Geography
Ten states: Missouri, Illinois, Iowa, Nebraska, Kansas, Oklahoma, Indiana, Ohio, Wisconsin, Minnesota.
Screening
Every respondent passed a consent screener; anyone who declined was screened out.
Reporting
Shares are unweighted percent of respondents, rounded half-up. Multi-select totals exceed 100 percent. Group breakdowns are reported only for groups of 30 or more respondents.
Status
Final. Figures come from the validated Pollfish respondent export, completed in September 2026.
Disclosure
Brain Recovery Centers commissioned and paid for this study.

How to cite

Please link to this page as the source: https://brainrecoverycenters.com/research/midwest-depression-care-survey-2026

Brain Recovery Centers. Midwest Depression Care Survey 2026: survey of 443 adults in ten Midwest states (Pollfish survey 395586438, fielded June 2026). https://brainrecoverycenters.com/research/midwest-depression-care-survey-2026

Spravato® (esketamine) is FDA-approved for treatment-resistant depression and for depressive symptoms in adults with major depressive disorder with acute suicidal ideation or behavior. It is not FDA-approved for concussion, traumatic brain injury, or post-concussion syndrome. Use in patients with a concussion history is based on clinical judgment regarding the depression component. We do not offer IV ketamine infusions. This page is educational and not medical advice. Individual results vary.

If you're in crisis right now, call or text 988 (Suicide & Crisis Lifeline), any hour; veterans can press 1. Brain Recovery Centers is not an emergency service.

Safety information

From the SPRAVATO Medication Guide, revised 09/2026. These are excerpts, word for word.

What is the most important information I should know about SPRAVATO?

SPRAVATO may cause serious side effects, including:

How can I watch for and try to prevent suicidal thoughts and actions in myself or a family member?

Pay close attention to any changes and tell your healthcare provider right away if you develop any new or sudden changes in mood, behavior, thoughts, or feelings, or if you develop suicidal thoughts or actions. This is very important when SPRAVATO is started or when the dose is changed.

Tell your healthcare provider or get emergency help right away if you or your family member have any of the following symptoms, especially if they are new, worse, or worry you:

If you're in crisis right now, call or text 988 (Suicide & Crisis Lifeline), or go to your nearest emergency room. Brain Recovery Centers is not an emergency service.

Who should not take SPRAVATO?

Do not take SPRAVATO if you:

If you are not sure if you have any of the above conditions, talk to your healthcare provider before taking SPRAVATO.

Before you take SPRAVATO, tell your healthcare provider about all of your medical conditions, including if you:

What should I avoid while taking SPRAVATO?

Do not drive, operate machinery, or do activities that require you to be fully alert and coordinated after taking SPRAVATO. Do not take part in these activities until the next day following a restful sleep.

What are the possible side effects of SPRAVATO?

Increased blood pressure. SPRAVATO can cause a temporary increase in your blood pressure that may last for about 4 hours after taking a dose. Your healthcare provider will check your blood pressure before taking SPRAVATO and for at least 2 hours after you take SPRAVATO. Tell your healthcare provider right away if you get chest pain, shortness of breath, sudden severe headache, change in vision, or seizures after taking SPRAVATO.

Problems with thinking clearly. Tell your healthcare provider if you have problems thinking or remembering.

Bladder problems. Tell your healthcare provider if you develop trouble urinating, such as a frequent or urgent need to urinate, pain when urinating, or urinating frequently at night.

The most common side effects of SPRAVATO include:

If these common side effects occur, they usually happen right after taking SPRAVATO and go away the same day.

These are not all the possible side effects of SPRAVATO. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the full Medication Guide (PDF)

Read the full Medication Guide (PDF)